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# Current challenges and needs

  • Available to more types of patients
  • Available for more types of cancer also solid tumors
  • Upscaling the car t cells treatment preparation process to lower the costs
  • Education programs for medical staff to identify and treat serious side effects
  • Guidelines with requirements for medical centers to be able to apply car t cell therapy themselves

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CAR T Cell therapy is now only approved to treat two type of blood cancers:
Leukemia: Tisagenlecleucel (Kymriah®)
non-Hodgkin lymphoma : Axicabtagene ciloleucel (Yescarta®)

Results of clinical trials on solid tumors have not been encouraging. But many solid tumors have multiple genomic mutations and the tumor can become resistant to treatment.

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The side effects of CAR T cell therapy, especially a condition known as cytokine release syndrome (CRS), can be life-threatening. Therefore EMA and FDA require that hospitals that use CAR T cell therapy have staff certified and trained to recognize and manage CRS.

The process of making CAR T cells is extremely complex. From start to finish, the process may take up two to three weeks.

If the treatment works as desired, the engineered T cells are on duty for the rest of the patient’s life.